Overview of CALEIDOS

CALEIDOS will be organised in the following Actions

The CALEIDOS project is organized in 19 actions. The first two actions of the project will define the regulatory and scientific context of the project, establishing the common language necessary for a good understanding and communication between regulators and scientists regarding the use of non-testing methods. In particular within Action A.1 we will describe in detail the regulatory basis, with clear requirements for the different use scenarios (e.g. dossier submission, classification and labelling (C&L), risk assessment and prioritisation). Action A.2 will address the scientific and technical part of the issue, for six endpoints of different nature: logP, bioconcentration factor, fish acute toxicity, mutagenicity (Ames test), carcinogenicity and reprotoxicity.

Once a shared basis has been achieved, we will address practical exercises within Action B.2 and following ones. In order to do this, we will take as material of the exercise the chemicals already registered for REACH. The collection of these chemicals will be done within Action B.1. Thus, once we will have identified the regulatory (from Action A.1) and scientific requirements (from Action A.2), and collected the data (from Action B.1), we will apply the selected models for the different purposes of their use: for registration (Action B.2), for C&L (Action B.3), and for carcinogenicity, mutagenicity and reprotoxicity (CMR) (Action B.4). The target of these three actions is to do exercises using the chemicals present at the ECHA web site, and the QSAR models to evaluate if they can provide acceptable results for these chemicals (i.e. good agreement of the predictions with the experimental values submitted to ECHA). The results will identify some possible use and critical chemicals. Within Action B.5 we will apply read across and grouping approaches to selected chemicals, taken from those for which QSAR gave no reliable results, from the successful ones and from the borderline situations. Action B.6 will produce a software platform with at least two QSAR models for each of the endpoints previously used: logP, bioconcentration factor, fish acute toxicity, mutagenicity (Ames test), carcinogenicity and reprotoxicity; in total at least 12 QSAR models will be available.

Action C.1 will monitor the broad impact of the project while Action C.2 will specifically focus on its socioeconomic impact.

Action D.1 will prepare a dedicated web site, containing the project results. Action D2 will produce the LIFE+ information boards. Action D.3 will prepare the Layman's report. Action D.4 will be dedicated to communication and dissemination, through a series of initiatives, and we will organize workshops on specific themes addressed within the project, in order to get further views, also from other stakeholders, such as industry.

Action E.1 will assure Management with a good organisation of the project and its smooth progress. Action E.2 will monitor the project progress. Action E.3 will promote networking within external initiatives. Action E.4 is dedicated to audit. Action E.5 is dedicated to After-LIFE initiatives.